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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEATR1
All Species:
20.3
Human Site:
S616
Identified Species:
34.36
UniProt:
Q9H583
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H583
NP_060542.4
2144
242370
S616
I
N
N
D
D
T
E
S
A
E
M
K
I
A
I
Chimpanzee
Pan troglodytes
XP_001156974
2144
242420
S616
I
N
N
D
D
T
E
S
A
E
M
K
I
A
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536334
2141
242568
S616
I
V
S
D
D
M
E
S
A
E
M
K
I
A
I
Cat
Felis silvestris
Mouse
Mus musculus
NP_659084
2143
242053
S616
I
T
S
N
D
I
E
S
P
D
M
K
I
A
I
Rat
Rattus norvegicus
NP_001101888
2143
241191
S616
I
I
D
N
D
V
E
S
P
D
T
K
M
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422958
2155
244590
S616
I
T
N
A
N
S
K
S
S
E
W
K
M
A
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q7SY48
2159
242032
C612
M
T
R
A
A
P
E
C
V
E
L
Q
M
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM75
2096
237201
E623
F
P
G
E
A
L
A
E
H
Q
H
K
A
L
R
Honey Bee
Apis mellifera
XP_393800
2028
231830
I589
N
D
D
A
D
V
D
I
T
M
E
V
L
K
S
Nematode Worm
Caenorhab. elegans
Q23495
1650
185210
K277
L
V
L
T
V
K
L
K
D
E
V
L
N
S
M
Sea Urchin
Strong. purpuratus
XP_794611
1635
181917
Y262
L
K
L
D
Y
L
D
Y
N
G
A
T
Y
M
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8Z4
2001
224001
K592
N
Q
T
D
S
T
E
K
V
T
S
A
M
F
P
Baker's Yeast
Sacchar. cerevisiae
P42945
1769
200063
D396
Y
L
S
E
I
L
E
D
K
S
Q
L
V
E
L
Red Bread Mold
Neurospora crassa
Q7RZM8
1788
196873
R415
V
D
Q
D
G
A
I
R
K
E
L
G
T
V
L
Conservation
Percent
Protein Identity:
100
99.5
N.A.
89.7
N.A.
83.8
84.9
N.A.
N.A.
65.5
N.A.
54.5
N.A.
28.6
30.5
21.1
24.4
Protein Similarity:
100
99.8
N.A.
95
N.A.
92.1
92.7
N.A.
N.A.
80.5
N.A.
73
N.A.
49.4
50.8
38.9
43.2
P-Site Identity:
100
100
N.A.
80
N.A.
60
46.6
N.A.
N.A.
46.6
N.A.
13.3
N.A.
6.6
6.6
6.6
13.3
P-Site Similarity:
100
100
N.A.
86.6
N.A.
80
73.3
N.A.
N.A.
80
N.A.
40
N.A.
20
33.3
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
21.2
23
Protein Similarity:
N.A.
N.A.
N.A.
43.4
40.2
42.2
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
33.3
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
15
8
8
0
22
0
8
8
8
43
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
15
15
43
43
0
15
8
8
15
0
0
0
0
0
% D
% Glu:
0
0
0
15
0
0
58
8
0
50
8
0
0
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
8
0
8
0
0
0
0
8
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% H
% Ile:
43
8
0
0
8
8
8
8
0
0
0
0
29
0
50
% I
% Lys:
0
8
0
0
0
8
8
15
15
0
0
50
0
8
0
% K
% Leu:
15
8
15
0
0
22
8
0
0
0
15
15
8
8
15
% L
% Met:
8
0
0
0
0
8
0
0
0
8
29
0
29
8
8
% M
% Asn:
15
15
22
15
8
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
8
0
0
0
8
0
0
15
0
0
0
0
0
8
% P
% Gln:
0
8
8
0
0
0
0
0
0
8
8
8
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% R
% Ser:
0
0
22
0
8
8
0
43
8
8
8
0
0
8
15
% S
% Thr:
0
22
8
8
0
22
0
0
8
8
8
8
8
8
0
% T
% Val:
8
15
0
0
8
15
0
0
15
0
8
8
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
8
0
0
0
8
0
0
8
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _